Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus
نویسندگان
چکیده
منابع مشابه
The HRAS1 minisatellite locus and risk of ovarian cancer.
Approximately 10% of ovarian cancers are due to mutations in highly penetrant inherited cancer susceptibility genes. The highly polymorphic HRAS1 minisatellite locus, located just downstream from the proto-oncogene H-ras-1 on chromosome 11p, consists of four common progenitor alleles and several dozen rare alleles, which apparently derive from mutations of the progenitors. Mutant alleles of thi...
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BACKGROUND A recent meta-analysis of 23 studies supported the empirically derived hypothesis that women who lack one of the four common minisatellite alleles at the HRAS1 locus are at increased risk of breast cancer. These studies relied on visual sizing of alleles on electrophoretic gels and may have underreported rare alleles. We determined whether this hypothesis applied to early-onset breas...
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Little is known about the general biology of minisatellites. The purpose of this study is to examine repeat mutations from the D1S80 minisatellite locus by sequence analysis to elucidate the mutational process at this locus. This is a highly polymorphic minisatellite locus, located in the subtelomeric region of chromosome 1. We have analyzed 90,000 human germline transmission events and found s...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 1999
ISSN: 1460-2083
DOI: 10.1093/hmg/8.3.515